多囊性腎病

polycystic kidney disease

Many people often ask:
"They have grown from being small to being aggressive. Du Zhong can be so vicious that he even bites his master."
"What's the explanation for his chronic illness and low resistance?"
"How do you explain why humans and animals live so long, while I, without illness or pain, live so short?"
In fact, all of the above are most likely health, behavioral, and immune system problems caused by inbreeding. Why do inbreeding cause more health problems?

All this can be attributed to genetic diseases, such as polycystic kidney disease (PKD), which is an autosomal dominant inherited disease (AD-PKD). As long as animals have this gene (PKD1), they are destined to develop the disease even if there is no carrier. If one parent has PKD1, there is a 50% chance that the offspring will also have PKD1. If both parents carry PKD1, the chance of inheriting the gene to the next generation jumps to at least 70%. PKD is common in Persian cats or cats with Persian ancestry, exotic shorthairs, and British shorthairs. Approximately 38% of Persian cats in the world, or 6% of cats, carry PKD1.

There are two diagnostic methods in current medicine:
1: Genetic testing (100% accurate, can be performed when animals are three or four months old, but not many countries have this technology.)
2: Ultrasonic examination (for example, when the animal is ten months old and examined by an experienced veterinarian, the accuracy can reach 95%). As we age, the water sacs in the kidneys will continue to become larger and more numerous, and slowly the number of normal kidney cells will decrease, and the kidneys will become abnormally large, eventually affecting kidney function and leading to chronic renal failure. Sometimes in addition to the kidneys, the liver may also have cysts. Most sick cats will begin to show symptoms when they are five to eight years old (average seven years old): such as frequent urination, polydipsia, weight loss, loss of appetite, vomiting, drowsiness, general weakness, etc.

In the private breeding model in Hong Kong, cats that have not yet developed the disease are often used to breed the next generation. From generation to generation, PKD1 will be passed down endlessly, leaving every cat unscathed and suffering from this genetic disease throughout its life. Of course, don’t expect that the so-called “owners” (actually cold-blooded domestic breeders) will be willing to spend money to treat small animals.

The next time you visit a pet store or buy a pet from your own breeder, there is a high chance that the “expected child” you see already has AD PKD. Cherish little life and be a responsible real owner. Support adoption, this is the right path for a civilized society.

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